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The best weight loss treatment UK depends on individual needs, health conditions, and accessibility. Popular options include NHS-approved weight loss injections like Wegovy and Mounjaro, which have shown significant results in reducing appetite and supporting long-term fat loss. For some, orlistat is available on prescription to block fat absorption, while structured lifestyle programmes such as Slimming World or NHS digital weight management services provide ongoing support. In severe cases, bariatric surgery may be recommended. Private clinics also offer tailored plans with medical supervision. The most effective approach combines medication, healthy diet, physical activity, and behavioural support.